Safe for long term use

• JRK’s 777 oil acts upon the impaired keratinocytes but does not kill or affect the normal cells.
• It does not have any side effects.

Proven to be safe under OECD guidelines for toxicity studies

Complete toxicity studies were conducted on Dr. JRK’s 777 oil under OECD (Organization for Economic Co-operation and Development) guidelines for Toxicity studies.

NAME OF THE STUDY	REFERENCE OECD NO	FINDINGS FOR Dr. JRK’s 777 OIL
Skin Sensitization in Guinea pig	406	Did not produce skin sensitization effect after 24 h and 48 h of removal of the patch
Effect on Mucus membrane	405	Did not produce mucus membrane irritation
In vitro Mammalian cell gene mutation test- chinese hamster ovary K1 cell line	476	Did not show any mutagenic effect
Bacterial reverse mutation test using S. typhimurium and E.coli WP2 uvr A	471	Did not show any mutagenic effect on all four strains of S. typhimurium and E.coli
Mammalian erythrocyte Micronucleus testing swiss albino mice.	474	Did not produce toxic effect on bone marrow and total polychromatic/ erythrocyte ratio (P/E).
Acute lethal dose	408	No change in the viscera/ organs and in the histological parameters was observed even in the animals that received high dose of the product.
Reproduction developmental toxicity screening	421	Did not produce reproduction and developmental toxicity. Pups did not reveal any abnormalities either at reproductive and histological level