Scientific Proof of Dr JRK's 777 Oil
Any well researched drug has to be evaluated on three important parameters like
Dr. JRK’s 777 oil has been evaluated on these three parameters through in vitro studies and clinical trials conducted at various institutions across the country in the last 25 years. It has proven therapeutic efficacy on psoriatic skin.
Dr. JRK’s 777 oil has been evaluated on these three parameters through in vitro studies and clinical trials conducted at various institutions across the country in the last 25 years. It has proven therapeutic efficacy on psoriatic skin.
Dr. JRK’s 777 oil has been evaluated on these three parameters through in vitro studies and clinical trials conducted at various institutions across the country in the last 25 years. It has proven therapeutic efficacy on psoriatic skin.
Clinical Studies
Quick and Extended Relief from Symptoms of Psoriasis- Clinical trial
Several clinical and preclinical studies that were carried out in various Government and non-government institutes proved that continuous use of Dr. JRK’s 777 oil gives faster and extended relief from psoriatic lesions. Its therapeutic efficacy has been endorsed by clinicians belonging to both Allopathic and Indian system of medicine for more than 25 years throughout India.
Postpone the recurrence
Clinical trials conducted in various parts of India prove the reduction of psoriatic lesions in 12 weeks’ usage of Dr.JRK’s 777 oil. Follow up study conducted over a period of 5 years confirmed that Dr.JRK’s 777 oil postponed the recurrence of lesions, minimized complications and prolonged the remission period.
Toxicity Studies
Safe for long term use
- JRK’s 777 oil acts upon the impaired keratinocytes but does not kill or affect the normal cells.
- It does not have any side effects.
Proven to be safe under OECD guidelines for toxicity studies
Complete toxicity studies were conducted on Dr. JRK’s 777 oil under OECD (Organization for Economic Co-operation and Development) guidelines for Toxicity studies.
| NAME OF THE STUDY | REFERENCE OECD NO | FINDINGS FOR Dr. JRK’s 777 OIL |
|
Skin Sensitization in Guinea pig |
406 | Did not produce skin sensitization effect after 24 h and 48 h of removal of the patch |
| Effect on Mucus membrane | 405 | Did not produce mucus membrane irritation |
| In vitro Mammalian cell gene mutation test- chinese hamster ovary K1 cell line | 476 | Did not show any mutagenic effect |
| Bacterial reverse mutation test using S. typhimurium and E.coli WP2 uvr A | 471 | Did not show any mutagenic effect on all four strains of S. typhimurium and E.coli |
| Mammalian erythrocyte Micronucleus testing swiss albino mice. | 474 | Did not produce toxic effect on bone marrow and total polychromatic/ erythrocyte ratio (P/E). |
| Acute lethal dose | 408 | No change in the viscera/ organs and in the histological parameters was observed even in the animals that received high dose of the product. |
| Reproduction developmental toxicity screening | 421 | Did not produce reproduction and developmental toxicity. Pups did not reveal any abnormalities either at reproductive and histological level |
In Vitro Studies
Reduces psoriatic scales and inflammation
- JRK’s 777 oil modulates immune reactions and reduces the proliferation rate of keratinocytes.
- It decreases the inflammatory reactions, itching and redness.
Invitro studies on HaCaT (Immortal HumanKeratinocytes) cell line
- The actives of Dr.JRK’s 777 oil inhibit the growth and proliferation of HaCaT cells i.e IC50-2.8mg/ml
- The effect of Dr.JRK’s 777 oil was proven to be ‘growth inhibitory’ and not cytotoxic in nature, hence Dr.JRK’s 777 oil is safe and effective in controlling the cell multiplication of HaCaT cells.
Dr.JRK’s 777 oil is studied for its anti-oxidant effect, rancidity and glycation. Scientific studies also prove that it will reduce the inflammation.
