Any well researched drug has to be evaluated on three important parameters like

Proven mechanism of action

Proven mechanism of action

Safety for long term use

Safety for long term use

Clinical effectiveness

Clinical effectiveness

Dr. JRK’s 777 oil has been evaluated on these three parameters through in vitro studies and clinical trials conducted at various institutions across the country in the last 25 years. It has proven therapeutic efficacy on psoriatic skin.

Quick and Extended Relief from Symptoms of Psoriasis- Clinical trial

Several clinical and preclinical studies that were carried out in various Government and non-government institutes proved that continuous use of Dr. JRK’s 777 oil gives faster and extended relief from psoriatic lesions.

Its therapeutic efficacy has been endorsed by clinicians belonging to both Allopathic and Indian system of medicine for more than 25 years throughout India.

Postpone the recurrence

Clinical trials conducted in various parts of India prove the reduction of psoriatic lesions in 12 weeks’ usage of Dr.JRK’s 777 oil.

Follow up study conducted over a period of 5 years confirmed that Dr.JRK’s 777 oil postponed the recurrence of lesions, minimized complications and prolonged the remission period.

Safe for long term use
  • JRK’s 777 oil acts upon the impaired keratinocytes but does not kill or affect the normal cells.
  • It does not have any side effects.
Proven to be safe under OECD guidelines for toxicity studies

Complete toxicity studies were conducted on Dr. JRK’s 777 oil under OECD (Organization for Economic Co-operation and Development) guidelines for Toxicity studies.

Skin Sensitization in Guinea pig 406 Did not produce skin sensitization effect after 24 h and 48 h of removal of the patch
Effect on Mucus membrane 405 Did not produce mucus membrane irritation
In vitro Mammalian cell gene mutation test- chinese hamster ovary K1 cell line 476 Did not show any mutagenic effect
Bacterial reverse mutation test using S. typhimurium and E.coli WP2 uvr A 471 Did not show any mutagenic effect on all four strains of S. typhimurium and E.coli
Mammalian erythrocyte Micronucleus testing swiss albino mice. 474 Did not produce toxic effect on bone marrow and total polychromatic/ erythrocyte ratio (P/E).
Acute lethal dose 408 No change in the viscera/ organs and in the histological parameters was observed even in the animals that received high dose of the product.
Reproduction developmental toxicity screening 421 Did not produce reproduction and developmental toxicity. Pups did not reveal any abnormalities either at reproductive and histological level
Reduces psoriatic scales and inflammation
  • JRK’s 777 oil modulates immune reactions and reduces the proliferation rate of keratinocytes.
  • It decreases the inflammatory reactions, itching and redness.

References for Clinical Studies:

  • Clinical trial of 1-3-2 topical therapy (Dr.JRK’s 777 oil, Psorolin oil,Psorolin ointment and Psorolin medicated bathing bar) and Psorolin oil. Ref -CTRI/2014/10/005143. International journal of clinical trials. 2018;5(3):121-6.
  • Effect of 777 oil on Non – Specific Dermatitis (777 oil – A Siddha Herbal Coded preparation. J. R. Krishnamurthy et. al. Journal of Research in Ayurveda and Siddha. 10 (3-4): 132-140,1987.
  • Efficacy of Topical application of 777 oil (Wrightia tinctoria) in the treatment of psoriasis. Dr. P. Lakshmi, Dr. G. Rathna Kumari. Department of Dermatology. King George Hospital, Vishakapattanam
  • Clinical study of Vetpalai (Wrightia tinctoria) oil in the treatment of Kalanjaga padai (Psoriasis).
  • Comparative study of calcipotriol and 777 oil in psoriasis. Dr. H. K. Kar, Dr. V. Jain, Dr. Raj Narayan. National conference of Indian Association of Dermatologist, Venerologist & Leperologist. 23-26,1997.
  • Herbal Treatment (Siddha) for psoriasis. K.K. Rao, J. R. Krishnamurthy Journal of Research in Ayurveda and Siddha. 9(3-4)124-134,1986.
  • Efficacy of 777 oil (Wrightia tinctoria) in the treatment of Psoriasis. Frederick Manuel The Antiseptic. 94 (3): 75-76,1997.
  • Clinical study of Vetpalai (Wrightia tinctoria) oil in the treatment of Kalanjaga padai (Psoriasis). J.R. Krishnamurty Central council for Research in Ayurveda and Siddha. 2 (1): 50-57,1982.

Reference for In Vitro Studies

  • Effect of 777 oil and Psorolin ointment in the multiplication of Hacat cells (Human Keratinocytes) by MTT assay. Study Report- AU – KBC Research Centre MIT Campus of Anna University, Chennai
  • Treatment of Psoriasis with Wrightia tinctoria leaf extract. Frederick Manuel et. al., Australian Journal of Dermatology. 38 (2)